Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This can be an impurity relevant to bortezomib, a proteasome inhibitor Employed in the treatment of multiple myeloma. Its synthesis or examine is very important for ensuring the purity and protection on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor inside the synthesis of abiraterone acetate, a drug used in the remedy of prostate most cancers by inhibiting androgen generation.
Imatinib Intermediate (CAS NO. 152460-ten-one): A vital compound from the synthesis of imatinib, a drug that targets unique varieties of cancer, including chronic myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats a variety of cancers like breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are generally intermediates within the synthesis of gemcitabine, an anti-most cancers drug. Their research is very important for optimizing the creation method and making sure substantial purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-5): Lapatinib is employed to take care of breast cancer, and these intermediates are involved in its generation.
Fulvestrant Intermediates: Fulvestrant is surely an estrogen receptor antagonist used in the procedure of 17-(3-pyridinyl)- breast cancer. Several intermediates help in the synthesis of the drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-16-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug powerful in treating cancers for example ovarian, breast, and lung most cancers.
3. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the therapy of colorectal cancer and compact cell lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-82-9): This compound is associated with the synthesis of adamantane derivatives, which have many programs, which include antiviral Attributes.
Vildagliptin (7a Intermediates: Used in the manufacture of vildagliptin, an oral drug for variety two diabetes that inhibits the enzyme DPP-four to control blood sugar levels.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-1): This compound is involved with the synthesis of assorted gluconic acid derivatives, that happen to be Employed in food, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 2: A precursor from the synthesis of canagliflozin, a medication utilized to deal with kind 2 diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).